This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for DNTTIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNTTIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNTTIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:93,345,396–93,346,457 | 533.3 kb | Distal (>10kb) Multiome HiCAR | 1003 | |
| chr1:93,447,560–93,449,029 | 431.1 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr1:93,622,085–93,622,775 | 256.8 kb | Distal (>10kb) Multiome | 282 | |
| chr1:93,678,776–93,679,511 | 199.9 kb | Distal (>10kb) Multiome | 96 | |
| chr1:93,680,733–93,682,277 | 197.2 kb | Distal (>10kb) Multiome | 717 | |
| chr1:93,814,055–93,816,005 | 63.9 kb | Distal (>10kb) Multiome | 533 | |
| chr1:93,820,560–93,821,453 | 58.1 kb | Distal (>10kb) Multiome | 160 | |
| chr1:93,845,985–93,846,892 | 32.9 kb | Distal (>10kb) Multiome | 732 | |
| chr1:93,846,995–93,848,315 | 31.6 kb | Distal (>10kb) Multiome | 954 | |
| chr1:93,878,726–93,879,400 | 33 bp | At TSS Multiome | 851 | |
| chr1:93,908,647–93,910,233 | 30.5 kb | Distal (>10kb) Multiome | 901 | |
| chr1:94,045,555–94,046,076 | 166.7 kb | Distal (>10kb) Multiome | 556 | |
| chr1:94,148,998–94,149,784 | 270.2 kb | Distal (>10kb) Multiome | 44 |
Genomic view of the DNTTIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.