Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for DNAH14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAH14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAH14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:224,113,911–224,114,795 | 815.5 kb | Distal (>10kb) Multiome HiCAR | 853 | |
| chr1:224,434,594–224,435,312 | 494.8 kb | Distal (>10kb) Multiome HiCAR | 865 | |
| chr1:224,498,011–224,499,031 | 431.0 kb | Distal (>10kb) Multiome HiCAR | 326 | |
| chr1:224,502,820–224,504,228 | 426.1 kb | Distal (>10kb) Multiome HiCAR | 820 | |
| chr1:224,639,152–224,640,098 | 290.1 kb | Distal (>10kb) Multiome HiCAR | 68 | |
| chr1:224,700,754–224,701,811 | 228.4 kb | Distal (>10kb) Multiome | 221 | |
| chr1:224,720,167–224,720,687 | 209.3 kb | Distal (>10kb) Multiome | 31 | |
| chr1:224,819,574–224,820,676 | 109.6 kb | Distal (>10kb) Multiome | 133 | |
| chr1:224,839,656–224,840,506 | 89.6 kb | Distal (>10kb) Multiome | 111 | |
| chr1:224,922,391–224,922,834 | 6.8 kb | Proximal (<10kb) | 196 | |
| chr1:224,929,306–224,930,138 | 7 bp | At TSS Multiome | 992 |
Genomic view of the DNAH14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.