The protein encoded by this gene is essential for the preassembly or stability of axonemal dynein arms, and is found only in organisms with motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia-18, a disorder characterized by abnormalities of motile cilia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for DNAAF5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAAF5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAAF5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:321,971–322,829 | 404.4 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr7:332,380–333,313 | 393.8 kb | Distal (>10kb) Multiome HiCAR | 649 | |
| chr7:515,390–516,162 | 210.8 kb | Distal (>10kb) Multiome | 84 | |
| chr7:518,879–521,101 | 206.6 kb | Distal (>10kb) Multiome | 523 | |
| chr7:726,194–727,335 | 8 bp | At TSS Multiome | 891 | |
| chr7:815,511–817,550 | 89.6 kb | Distal (>10kb) Multiome | 640 | |
| chr7:875,946–877,507 | 149.9 kb | Distal (>10kb) Multiome | 918 | |
| chr7:901,112–902,113 | 175.0 kb | Distal (>10kb) Multiome | 376 | |
| chr7:953,606–955,017 | 227.9 kb | Distal (>10kb) Multiome | 482 | |
| chr7:974,909–975,889 | 248.8 kb | Distal (>10kb) Multiome | 860 | |
| chr7:992,812–993,637 | 266.6 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the DNAAF5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.