Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in cytosol; nucleus; and spindle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DLGAP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLGAP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLGAP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:54,901,803–54,903,430 | 288.7 kb | Distal (>10kb) Multiome | 886 | |
| chr14:55,026,752–55,027,732 | 164.3 kb | Distal (>10kb) Multiome | 918 | |
| chr14:55,051,004–55,052,455 | 139.8 kb | Distal (>10kb) Multiome | 1079 | |
| chr14:55,103,022–55,103,627 | 88.2 kb | Distal (>10kb) Multiome | 700 | |
| chr14:55,128,954–55,130,369 | 62.2 kb | Distal (>10kb) Multiome | 569 | |
| chr14:55,191,089–55,192,110 | 95 bp | At TSS Multiome | 702 | |
| chr14:55,270,885–55,272,249 | 79.8 kb | Distal (>10kb) Multiome | 901 | |
| chr14:55,275,685–55,276,150 | 84.3 kb | Distal (>10kb) Multiome | 15 | |
| chr14:55,411,377–55,412,204 | 220.3 kb | Distal (>10kb) Multiome | 795 | |
| chr14:56,659,300–56,659,979 | 1468.1 kb | Distal (>10kb) Multiome HiCAR | 126 |
Genomic view of the DLGAP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.