This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for DIP2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIP2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIP2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:50,232,842–50,233,291 | 271.9 kb | Distal (>10kb) Multiome | 105 | |
| chr12:50,283,141–50,284,081 | 221.4 kb | Distal (>10kb) Multiome | 750 | |
| chr12:50,400,518–50,401,658 | 104.1 kb | Distal (>10kb) Multiome | 948 | |
| chr12:50,504,583–50,505,803 | 32 bp | At TSS Multiome | 806 | |
| chr12:50,763,385–50,764,948 | 259.2 kb | Distal (>10kb) Multiome | 1004 |
Genomic view of the DIP2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.