This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for DHX29. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHX29 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHX29, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:55,029,649–55,030,875 | 277.3 kb | Distal (>10kb) Multiome | 91 | |
| chr5:55,172,818–55,174,056 | 134.3 kb | Distal (>10kb) Multiome | 485 | |
| chr5:55,176,186–55,176,916 | 131.1 kb | Distal (>10kb) Multiome | 520 | |
| chr5:55,220,318–55,221,200 | 87.0 kb | Distal (>10kb) Multiome | 183 | |
| chr5:55,226,323–55,227,998 | 81.0 kb | Distal (>10kb) Multiome | 708 | |
| chr5:55,232,241–55,234,359 | 74.0 kb | Distal (>10kb) Multiome | 615 | |
| chr5:55,307,204–55,308,263 | 68 bp | At TSS Multiome | 873 | |
| chr5:55,406,222–55,406,887 | 98.8 kb | Distal (>10kb) Multiome | 40 | |
| chr5:55,484,537–55,485,441 | 177.1 kb | Distal (>10kb) Multiome | 208 | |
| chr5:55,497,392–55,498,099 | 190.1 kb | Distal (>10kb) Multiome | 88 | |
| chr5:55,534,173–55,536,366 | 227.3 kb | Distal (>10kb) Multiome | 894 | |
| chr5:55,711,869–55,712,819 | 404.7 kb | Distal (>10kb) Multiome HiCAR | 772 |
Genomic view of the DHX29 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.