In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DGUOK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGUOK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGUOK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:73,707,107–73,707,579 | 219.6 kb | Distal (>10kb) Multiome | 38 | |
| chr2:73,736,841–73,737,678 | 189.5 kb | Distal (>10kb) Multiome | 952 | |
| chr2:73,779,673–73,780,474 | 146.8 kb | Distal (>10kb) Multiome | 767 | |
| chr2:73,828,734–73,829,492 | 97.9 kb | Distal (>10kb) Multiome | 774 | |
| chr2:73,921,096–73,921,666 | 5.5 kb | Proximal (<10kb) Multiome | 284 | |
| chr2:73,926,648–73,927,193 | 11 bp | At TSS Multiome | 961 | |
| chr2:73,981,145–73,981,910 | 54.7 kb | Distal (>10kb) Multiome | 483 | |
| chr2:73,983,451–73,985,871 | 58.5 kb | Distal (>10kb) Multiome | 821 | |
| chr2:74,002,059–74,003,348 | 75.8 kb | Distal (>10kb) Multiome | 514 | |
| chr2:74,008,705–74,009,321 | 82.1 kb | Distal (>10kb) Multiome | 142 | |
| chr2:74,026,198–74,026,578 | 99.6 kb | Distal (>10kb) Multiome | 88 | |
| chr2:74,119,987–74,120,643 | 193.5 kb | Distal (>10kb) Multiome | 969 | |
| chr2:74,147,573–74,148,843 | 221.1 kb | Distal (>10kb) Multiome HiCAR | 884 | |
| chr2:74,178,147–74,179,324 | 252.0 kb | Distal (>10kb) Multiome | 869 | |
| chr2:74,187,993–74,188,519 | 261.3 kb | Distal (>10kb) Multiome | 192 | |
| chr2:74,198,074–74,199,486 | 271.7 kb | Distal (>10kb) Multiome | 1098 |
Genomic view of the DGUOK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.