Predicted to enable GTPase activator activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DEPDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEPDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEPDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:67,832,601–67,833,942 | 663.8 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr1:68,231,101–68,233,483 | 264.5 kb | Distal (>10kb) Multiome | 557 | |
| chr1:68,276,130–68,277,060 | 220.5 kb | Distal (>10kb) Multiome | 216 | |
| chr1:68,293,575–68,295,170 | 202.8 kb | Distal (>10kb) Multiome | 309 | |
| chr1:68,496,039–68,497,758 | 75 bp | At TSS Multiome | 831 | |
| chr1:69,311,926–69,313,463 | 815.5 kb | Distal (>10kb) Multiome HiCAR | 223 | |
| chr1:69,566,791–69,570,680 | 1070.4 kb | Distal (>10kb) Multiome HiCAR | 609 | |
| chr1:70,204,918–70,206,272 | 1708.6 kb | Distal (>10kb) Multiome HiCAR | 947 | |
| chr1:70,220,975–70,221,995 | 1724.4 kb | Distal (>10kb) Multiome HiCAR | 912 |
Genomic view of the DEPDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.