This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DENR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:122,500,206–122,501,493 | 251.9 kb | Distal (>10kb) Multiome | 955 | |
| chr12:122,526,435–122,527,753 | 225.8 kb | Distal (>10kb) Multiome | 956 | |
| chr12:122,751,194–122,751,767 | 1.5 kb | Proximal (<10kb) Multiome | 128 | |
| chr12:122,752,332–122,753,299 | 75 bp | At TSS Multiome | 978 | |
| chr12:122,774,223–122,774,865 | 21.7 kb | Distal (>10kb) Multiome | 445 | |
| chr12:122,834,656–122,836,128 | 82.6 kb | Distal (>10kb) Multiome | 514 | |
| chr12:122,895,832–122,896,391 | 143.3 kb | Distal (>10kb) Multiome | 774 | |
| chr12:122,965,963–122,966,953 | 213.7 kb | Distal (>10kb) Multiome | 576 | |
| chr12:122,974,115–122,975,704 | 222.0 kb | Distal (>10kb) Multiome | 889 | |
| chr12:122,980,138–122,981,155 | 227.8 kb | Distal (>10kb) Multiome | 817 | |
| chr12:123,049,639–123,050,104 | 297.0 kb | Distal (>10kb) Multiome | 45 |
Genomic view of the DENR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.