Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus; protein localization to plasma membrane; and regulation of Rab protein signal transduction. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND4C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND4C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND4C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:19,048,607–19,050,217 | 181.5 kb | Distal (>10kb) Multiome | 993 | |
| chr9:19,102,191–19,103,414 | 127.8 kb | Distal (>10kb) Multiome | 770 | |
| chr9:19,126,915–19,128,564 | 103.2 kb | Distal (>10kb) Multiome | 808 | |
| chr9:19,201,888–19,203,074 | 28.4 kb | Distal (>10kb) Multiome | 569 | |
| chr9:19,223,736–19,224,341 | 6.5 kb | Proximal (<10kb) | 115 | |
| chr9:19,229,553–19,231,458 | 250 bp | At TSS Multiome | 973 | |
| chr9:19,379,591–19,380,878 | 149.5 kb | Distal (>10kb) Multiome | 1052 | |
| chr9:19,408,145–19,409,950 | 178.1 kb | Distal (>10kb) Multiome | 773 | |
| chr9:19,446,288–19,446,838 | 215.9 kb | Distal (>10kb) Multiome | 110 | |
| chr9:19,464,477–19,465,453 | 234.2 kb | Distal (>10kb) Multiome | 427 |
Genomic view of the DENND4C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.