This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DEDD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEDD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEDD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:160,681,274–160,681,823 | 451.0 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr1:160,726,492–160,727,108 | 405.7 kb | Distal (>10kb) Multiome HiCAR | 322 | |
| chr1:160,910,331–160,911,177 | 221.9 kb | Distal (>10kb) Multiome | 97 | |
| chr1:160,947,055–160,947,669 | 185.2 kb | Distal (>10kb) Multiome | 35 | |
| chr1:160,948,561–160,949,851 | 183.2 kb | Distal (>10kb) Multiome | 173 | |
| chr1:160,981,323–160,982,552 | 150.8 kb | Distal (>10kb) Multiome | 156 | |
| chr1:161,020,536–161,021,920 | 111.3 kb | Distal (>10kb) Multiome | 846 | |
| chr1:161,038,489–161,039,130 | 93.6 kb | Distal (>10kb) Multiome | 468 | |
| chr1:161,045,080–161,046,516 | 86.6 kb | Distal (>10kb) Multiome | 927 | |
| chr1:161,097,691–161,099,047 | 34.3 kb | Distal (>10kb) Multiome | 829 | |
| chr1:161,117,504–161,118,419 | 14.5 kb | Distal (>10kb) Multiome | 794 | |
| chr1:161,131,760–161,133,351 | 88 bp | At TSS Multiome | 956 | |
| chr1:161,153,700–161,154,461 | 21.4 kb | Distal (>10kb) Multiome | 816 | |
| chr1:161,158,928–161,160,167 | 26.9 kb | Distal (>10kb) Multiome | 706 | |
| chr1:161,165,740–161,167,170 | 33.8 kb | Distal (>10kb) Multiome | 888 | |
| chr1:161,176,874–161,177,972 | 44.9 kb | Distal (>10kb) Multiome | 910 | |
| chr1:161,198,215–161,199,209 | 66.0 kb | Distal (>10kb) Multiome | 357 | |
| chr1:161,201,572–161,202,783 | 69.7 kb | Distal (>10kb) Multiome | 852 | |
| chr1:161,225,326–161,226,910 | 93.3 kb | Distal (>10kb) Multiome | 710 | |
| chr1:161,227,235–161,227,802 | 94.9 kb | Distal (>10kb) Multiome | 372 | |
| chr1:161,258,515–161,259,098 | 126.2 kb | Distal (>10kb) Multiome | 281 | |
| chr1:161,305,737–161,306,708 | 173.7 kb | Distal (>10kb) Multiome | 430 | |
| chr1:161,313,977–161,314,703 | 181.8 kb | Distal (>10kb) Multiome | 824 | |
| chr1:161,389,675–161,390,784 | 257.5 kb | Distal (>10kb) Multiome | 866 | |
| chr1:161,399,098–161,400,259 | 267.1 kb | Distal (>10kb) Multiome | 1040 |
Genomic view of the DEDD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.