Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be located in cytoplasm; membrane; and nucleus. Implicated in orofaciodigital syndrome V. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DDX59. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDX59 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDX59, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:200,409,102–200,410,859 | 259.8 kb | Distal (>10kb) Multiome | 818 | |
| chr1:200,411,526–200,412,290 | 258.1 kb | Distal (>10kb) Multiome | 202 | |
| chr1:200,620,328–200,621,096 | 49.1 kb | Distal (>10kb) Multiome | 739 | |
| chr1:200,665,949–200,666,168 | 3.7 kb | Proximal (<10kb) | 54 | |
| chr1:200,668,644–200,669,109 | 797 bp | At TSS | 68 | |
| chr1:200,669,293–200,670,631 | 3 bp | At TSS Multiome | 1078 | |
| chr1:200,738,299–200,740,095 | 69.1 kb | Distal (>10kb) Multiome | 831 | |
| chr1:200,890,766–200,892,246 | 221.5 kb | Distal (>10kb) Multiome | 761 | |
| chr1:200,915,808–200,916,700 | 246.4 kb | Distal (>10kb) Multiome | 219 |
Genomic view of the DDX59 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.