The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DCTN6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCTN6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCTN6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:29,874,798–29,875,362 | 281.2 kb | Distal (>10kb) Multiome | 162 | |
| chr8:29,990,565–29,991,896 | 165.3 kb | Distal (>10kb) Multiome | 363 | |
| chr8:30,005,068–30,006,568 | 150.9 kb | Distal (>10kb) Multiome | 99 | |
| chr8:30,011,371–30,011,980 | 144.6 kb | Distal (>10kb) Multiome | 36 | |
| chr8:30,033,186–30,034,812 | 121.9 kb | Distal (>10kb) Multiome | 337 | |
| chr8:30,034,989–30,035,701 | 120.8 kb | Distal (>10kb) Multiome | 47 | |
| chr8:30,082,008–30,083,590 | 73.2 kb | Distal (>10kb) Multiome | 1023 | |
| chr8:30,087,943–30,088,717 | 68.1 kb | Distal (>10kb) Multiome | 89 | |
| chr8:30,094,567–30,095,766 | 61.0 kb | Distal (>10kb) Multiome | 743 | |
| chr8:30,155,587–30,157,134 | 34 bp | At TSS Multiome | 798 | |
| chr8:30,157,640–30,157,817 | 1.3 kb | Proximal (<10kb) | 269 | |
| chr8:30,227,068–30,227,925 | 71.3 kb | Distal (>10kb) Multiome | 398 | |
| chr8:30,339,419–30,340,356 | 183.4 kb | Distal (>10kb) Multiome | 302 | |
| chr8:30,382,832–30,383,366 | 226.6 kb | Distal (>10kb) Multiome | 188 | |
| chr8:30,383,830–30,385,512 | 228.1 kb | Distal (>10kb) Multiome | 578 | |
| chr8:30,423,017–30,423,578 | 267.0 kb | Distal (>10kb) Multiome | 306 | |
| chr8:30,442,133–30,442,945 | 286.2 kb | Distal (>10kb) Multiome | 264 | |
| chr8:30,541,211–30,542,932 | 385.3 kb | Distal (>10kb) Multiome HiCAR | 253 | |
| chr8:30,555,639–30,556,644 | 399.6 kb | Distal (>10kb) Multiome HiCAR | 396 |
Genomic view of the DCTN6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.