This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for DCP1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCP1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCP1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:1,720,538–1,721,023 | 283.8 kb | Distal (>10kb) Multiome | 64 | |
| chr12:1,794,646–1,795,302 | 209.6 kb | Distal (>10kb) Multiome | 100 | |
| chr12:1,795,674–1,796,431 | 208.3 kb | Distal (>10kb) Multiome | 643 | |
| chr12:2,003,890–2,004,937 | 52 bp | At TSS Multiome | 942 | |
| chr12:2,034,959–2,035,597 | 30.6 kb | Distal (>10kb) Multiome | 564 | |
| chr12:2,052,516–2,053,357 | 48.4 kb | Distal (>10kb) Multiome | 254 |
Genomic view of the DCP1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.