Predicted to be involved in negative regulation of fatty acid biosynthetic process. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DCAF5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:68,862,998–68,863,526 | 289.9 kb | Distal (>10kb) Multiome | 296 | |
| chr14:68,937,585–68,939,538 | 214.5 kb | Distal (>10kb) Multiome | 580 | |
| chr14:68,977,829–68,980,593 | 173.7 kb | Distal (>10kb) Multiome | 919 | |
| chr14:69,050,256–69,051,065 | 102.5 kb | Distal (>10kb) Multiome | 105 | |
| chr14:69,129,353–69,129,859 | 23.6 kb | Distal (>10kb) Multiome | 260 | |
| chr14:69,142,446–69,143,163 | 9.4 kb | Proximal (<10kb) | 26 | |
| chr14:69,149,737–69,150,445 | 3.1 kb | Proximal (<10kb) Multiome | 70 | |
| chr14:69,151,308–69,153,780 | 1.5 kb | Proximal (<10kb) Multiome | 936 | |
| chr14:69,154,882–69,155,096 | 2.3 kb | Proximal (<10kb) | 114 | |
| chr14:69,191,332–69,192,132 | 38.5 kb | Distal (>10kb) Multiome | 977 | |
| chr14:69,259,475–69,261,593 | 106.7 kb | Distal (>10kb) Multiome | 477 | |
| chr14:69,397,842–69,399,035 | 245.4 kb | Distal (>10kb) Multiome | 926 |
Genomic view of the DCAF5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.