Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DBF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DBF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DBF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:87,600,126–87,601,238 | 275.5 kb | Distal (>10kb) Multiome | 659 | |
| chr7:87,627,436–87,629,300 | 247.9 kb | Distal (>10kb) Multiome | 723 | |
| chr7:87,747,116–87,748,307 | 128.7 kb | Distal (>10kb) Multiome | 120 | |
| chr7:87,875,330–87,875,523 | 691 bp | At TSS | 69 | |
| chr7:87,875,696–87,877,237 | 135 bp | At TSS Multiome | 999 | |
| chr7:87,926,435–87,927,491 | 50.8 kb | Distal (>10kb) Multiome | 329 | |
| chr7:87,933,597–87,935,535 | 58.0 kb | Distal (>10kb) Multiome | 864 |
Genomic view of the DBF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.