Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CYSTM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYSTM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYSTM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:139,897,165–139,897,870 | 277.7 kb | Distal (>10kb) Multiome | 20 | |
| chr5:139,903,738–139,904,936 | 270.9 kb | Distal (>10kb) Multiome | 298 | |
| chr5:139,955,312–139,956,123 | 219.5 kb | Distal (>10kb) Multiome | 118 | |
| chr5:139,968,615–139,969,112 | 206.3 kb | Distal (>10kb) Multiome | 565 | |
| chr5:140,038,152–140,038,948 | 136.6 kb | Distal (>10kb) Multiome | 241 | |
| chr5:140,042,572–140,043,835 | 131.9 kb | Distal (>10kb) Multiome | 523 | |
| chr5:140,107,138–140,108,849 | 67.3 kb | Distal (>10kb) Multiome | 993 | |
| chr5:140,112,921–140,114,941 | 61.1 kb | Distal (>10kb) Multiome | 811 | |
| chr5:140,145,842–140,146,580 | 29.1 kb | Distal (>10kb) Multiome | 366 | |
| chr5:140,157,178–140,157,756 | 17.8 kb | Distal (>10kb) Multiome | 504 | |
| chr5:140,174,682–140,176,221 | 84 bp | At TSS Multiome | 959 | |
| chr5:140,183,071–140,183,262 | 7.9 kb | Proximal (<10kb) | 95 | |
| chr5:140,302,631–140,303,538 | 128.0 kb | Distal (>10kb) Multiome | 552 | |
| chr5:140,345,869–140,347,147 | 171.5 kb | Distal (>10kb) Multiome | 671 | |
| chr5:140,363,055–140,363,697 | 188.2 kb | Distal (>10kb) Multiome | 542 | |
| chr5:140,372,779–140,373,538 | 198.0 kb | Distal (>10kb) Multiome | 302 | |
| chr5:140,400,395–140,402,925 | 226.4 kb | Distal (>10kb) Multiome | 1129 |
Genomic view of the CYSTM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.