This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CYP26A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYP26A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYP26A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:92,789,669–92,790,231 | 286.4 kb | Distal (>10kb) Multiome | 103 | |
| chr10:92,848,153–92,849,292 | 227.8 kb | Distal (>10kb) Multiome | 664 | |
| chr10:93,062,482–93,063,469 | 13.5 kb | Distal (>10kb) Multiome | 217 | |
| chr10:93,065,937–93,066,430 | 7.5 kb | Proximal (<10kb) | 105 | |
| chr10:93,068,367–93,069,020 | 4.9 kb | Proximal (<10kb) | 162 | |
| chr10:93,071,791–93,072,763 | 4.3 kb | Proximal (<10kb) Multiome | 474 | |
| chr10:93,072,870–93,075,143 | 2.5 kb | Proximal (<10kb) Multiome | 506 | |
| chr10:93,079,595–93,081,000 | 4.0 kb | Proximal (<10kb) Multiome | 247 | |
| chr10:93,198,100–93,199,722 | 122.2 kb | Distal (>10kb) Multiome | 323 | |
| chr10:93,248,667–93,249,274 | 172.6 kb | Distal (>10kb) Multiome | 252 | |
| chr10:93,252,728–93,253,353 | 176.7 kb | Distal (>10kb) Multiome | 21 | |
| chr10:93,272,746–93,273,707 | 196.8 kb | Distal (>10kb) Multiome HiCAR | 280 | |
| chr10:93,280,194–93,281,735 | 204.6 kb | Distal (>10kb) Multiome HiCAR | 353 | |
| chr10:93,305,125–93,305,605 | 229.0 kb | Distal (>10kb) Multiome HiCAR | 88 | |
| chr10:93,316,753–93,317,413 | 240.7 kb | Distal (>10kb) Multiome HiCAR | 114 | |
| chr10:93,333,260–93,334,502 | 257.4 kb | Distal (>10kb) Multiome HiCAR | 227 |
Genomic view of the CYP26A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.