This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CYLD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYLD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYLD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:50,467,766–50,468,772 | 273.9 kb | Distal (>10kb) Multiome | 685 | |
| chr16:50,539,882–50,540,391 | 202.0 kb | Distal (>10kb) Multiome | 134 | |
| chr16:50,547,325–50,549,168 | 193.8 kb | Distal (>10kb) Multiome | 774 | |
| chr16:50,665,176–50,665,840 | 76.6 kb | Distal (>10kb) Multiome | 469 | |
| chr16:50,741,394–50,742,754 | 163 bp | At TSS Multiome | 739 | |
| chr16:50,806,109–50,806,812 | 64.4 kb | Distal (>10kb) Multiome | 521 | |
| chr16:50,879,714–50,880,313 | 137.9 kb | Distal (>10kb) Multiome | 122 |
Genomic view of the CYLD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.