Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CUTC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CUTC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CUTC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:99,519,844–99,520,769 | 212.0 kb | Distal (>10kb) Multiome | 331 | |
| chr10:99,522,567–99,524,013 | 209.0 kb | Distal (>10kb) Multiome | 201 | |
| chr10:99,527,131–99,527,911 | 204.7 kb | Distal (>10kb) Multiome | 89 | |
| chr10:99,532,575–99,533,287 | 199.4 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,534,863–99,536,063 | 196.9 kb | Distal (>10kb) Multiome | 193 | |
| chr10:99,536,574–99,538,002 | 195.2 kb | Distal (>10kb) Multiome | 279 | |
| chr10:99,619,825–99,621,725 | 111.6 kb | Distal (>10kb) Multiome | 1070 | |
| chr10:99,658,847–99,660,052 | 72.9 kb | Distal (>10kb) Multiome | 728 | |
| chr10:99,731,799–99,732,929 | 6 bp | At TSS Multiome | 941 | |
| chr10:99,913,671–99,914,615 | 181.8 kb | Distal (>10kb) Multiome | 256 | |
| chr10:100,009,381–100,010,564 | 277.7 kb | Distal (>10kb) Multiome | 647 |
Genomic view of the CUTC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.