Enables protein phosphatase 2A binding activity. Acts upstream of or within negative regulation of transmembrane transport; negative regulation of transporter activity; and protein dephosphorylation. Located in actin cytoskeleton. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CTTNBP2NL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTTNBP2NL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTTNBP2NL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,369,701–112,370,152 | 26.4 kb | Distal (>10kb) Multiome | 364 | |
| chr1:112,390,678–112,391,531 | 5.2 kb | Proximal (<10kb) Multiome | 470 | |
| chr1:112,395,753–112,396,890 | 56 bp | At TSS Multiome | 600 | |
| chr1:112,465,931–112,466,532 | 70.1 kb | Distal (>10kb) Multiome HiCAR | 686 | |
| chr1:112,501,804–112,502,551 | 106.0 kb | Distal (>10kb) Multiome | 420 | |
| chr1:112,507,925–112,508,314 | 111.8 kb | Distal (>10kb) Multiome | 122 | |
| chr1:112,508,429–112,509,558 | 112.8 kb | Distal (>10kb) Multiome | 413 | |
| chr1:112,524,298–112,524,779 | 128.3 kb | Distal (>10kb) Multiome | 127 | |
| chr1:112,618,652–112,620,129 | 223.5 kb | Distal (>10kb) Multiome | 956 | |
| chr1:112,674,125–112,675,737 | 279.2 kb | Distal (>10kb) Multiome | 910 | |
| chr1:112,700,203–112,701,476 | 304.6 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr1:112,704,514–112,705,591 | 309.0 kb | Distal (>10kb) Multiome HiCAR | 694 | |
| chr1:112,706,536–112,707,966 | 311.1 kb | Distal (>10kb) Multiome HiCAR | 784 | |
| chr1:112,714,149–112,716,774 | 320.4 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr1:113,929,054–113,930,528 | 1533.4 kb | Distal (>10kb) Multiome HiCAR | 1003 |
Genomic view of the CTTNBP2NL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.