This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for CTC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:7,971,685–7,972,375 | 276.1 kb | Distal (>10kb) Multiome | 45 | |
| chr17:7,989,908–7,990,676 | 257.8 kb | Distal (>10kb) Multiome | 652 | |
| chr17:8,015,966–8,016,968 | 232.0 kb | Distal (>10kb) Multiome | 339 | |
| chr17:8,068,609–8,069,844 | 179.2 kb | Distal (>10kb) Multiome | 100 | |
| chr17:8,079,261–8,080,640 | 168.6 kb | Distal (>10kb) Multiome | 613 | |
| chr17:8,109,567–8,110,530 | 137.8 kb | Distal (>10kb) Multiome | 360 | |
| chr17:8,117,780–8,119,396 | 129.1 kb | Distal (>10kb) Multiome | 684 | |
| chr17:8,119,590–8,122,560 | 127.4 kb | Distal (>10kb) Multiome | 968 | |
| chr17:8,123,407–8,124,386 | 123.9 kb | Distal (>10kb) Multiome | 296 | |
| chr17:8,125,308–8,126,995 | 122.3 kb | Distal (>10kb) Multiome | 724 | |
| chr17:8,138,425–8,139,804 | 109.1 kb | Distal (>10kb) Multiome | 981 | |
| chr17:8,151,026–8,151,640 | 96.8 kb | Distal (>10kb) Multiome | 435 | |
| chr17:8,151,914–8,152,786 | 95.6 kb | Distal (>10kb) Multiome | 633 | |
| chr17:8,153,878–8,154,864 | 93.7 kb | Distal (>10kb) Multiome | 644 | |
| chr17:8,155,928–8,157,418 | 91.4 kb | Distal (>10kb) Multiome | 789 | |
| chr17:8,162,377–8,163,907 | 85.0 kb | Distal (>10kb) Multiome | 637 | |
| chr17:8,172,460–8,174,346 | 74.5 kb | Distal (>10kb) Multiome | 1196 | |
| chr17:8,175,900–8,176,943 | 71.6 kb | Distal (>10kb) Multiome | 601 | |
| chr17:8,185,937–8,188,084 | 60.3 kb | Distal (>10kb) Multiome | 1065 | |
| chr17:8,189,376–8,190,688 | 57.8 kb | Distal (>10kb) Multiome | 748 | |
| chr17:8,192,025–8,192,719 | 55.7 kb | Distal (>10kb) Multiome | 452 | |
| chr17:8,210,139–8,210,786 | 37.4 kb | Distal (>10kb) Multiome | 778 | |
| chr17:8,220,662–8,224,088 | 25.1 kb | Distal (>10kb) Multiome | 1171 | |
| chr17:8,226,529–8,227,280 | 21.3 kb | Distal (>10kb) Multiome | 565 | |
| chr17:8,247,519–8,249,589 | 1.3 kb | Proximal (<10kb) Multiome | 914 | |
| chr17:8,288,100–8,289,230 | 40.8 kb | Distal (>10kb) Multiome | 751 | |
| chr17:8,295,073–8,296,021 | 47.4 kb | Distal (>10kb) Multiome | 739 | |
| chr17:8,310,033–8,310,555 | 62.2 kb | Distal (>10kb) Multiome | 98 | |
| chr17:8,313,329–8,313,824 | 65.5 kb | Distal (>10kb) Multiome | 30 | |
| chr17:8,376,215–8,376,918 | 128.6 kb | Distal (>10kb) Multiome | 888 | |
| chr17:8,382,925–8,384,028 | 135.4 kb | Distal (>10kb) Multiome | 981 | |
| chr17:8,435,307–8,436,885 | 187.8 kb | Distal (>10kb) Multiome | 847 |
Genomic view of the CTC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.