Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for CTBS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTBS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTBS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:84,479,129–84,479,871 | 95.0 kb | Distal (>10kb) Multiome | 843 | |
| chr1:84,505,605–84,506,945 | 68.1 kb | Distal (>10kb) Multiome | 937 | |
| chr1:84,573,555–84,574,858 | 115 bp | At TSS Multiome | 896 | |
| chr1:84,580,644–84,581,205 | 6.2 kb | Proximal (<10kb) | 26 | |
| chr1:84,582,867–84,584,410 | 9.0 kb | Proximal (<10kb) Multiome | 288 | |
| chr1:84,602,350–84,604,845 | 28.9 kb | Distal (>10kb) Multiome | 490 | |
| chr1:84,611,743–84,612,319 | 37.6 kb | Distal (>10kb) Multiome | 53 | |
| chr1:84,620,449–84,621,260 | 46.5 kb | Distal (>10kb) Multiome | 711 | |
| chr1:84,689,823–84,691,321 | 116.1 kb | Distal (>10kb) Multiome | 784 |
Genomic view of the CTBS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.