CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for CSRP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSRP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSRP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:76,763,225–76,765,030 | 114.8 kb | Distal (>10kb) Multiome | 982 | |
| chr12:76,780,975–76,782,664 | 97.0 kb | Distal (>10kb) Multiome | 241 | |
| chr12:76,872,409–76,872,961 | 6.4 kb | Proximal (<10kb) Multiome | 106 | |
| chr12:76,874,333–76,874,854 | 4.2 kb | Proximal (<10kb) | 71 | |
| chr12:76,878,056–76,880,114 | 37 bp | At TSS Multiome | 765 | |
| chr12:77,064,730–77,066,404 | 186.6 kb | Distal (>10kb) Multiome | 820 |
Genomic view of the CSRP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.