The protein encoded by this gene is thought to be involved in the control of complement cascade of the immune system. Defects in this gene have been associated with schizophrenia. This gene may act as a tumor suppressor for colorectal cancer. [provided by RefSeq, Jan 2020]
Transcription factors with Perturb-seq knockdown data for CSMD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSMD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSMD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:33,805,861–33,806,385 | 359.0 kb | Distal (>10kb) Multiome HiCAR | 41 | |
| chr1:33,859,337–33,859,839 | 305.7 kb | Distal (>10kb) Multiome HiCAR | 13 | |
| chr1:33,902,265–33,903,150 | 262.5 kb | Distal (>10kb) Multiome | 139 | |
| chr1:34,162,968–34,163,766 | 2.0 kb | Proximal (<10kb) Multiome | 254 | |
| chr1:34,164,328–34,165,419 | at TSS | At TSS | 182 | |
| chr1:34,165,808–34,167,782 | 1.7 kb | Proximal (<10kb) Multiome | 157 | |
| chr1:34,749,736–34,750,608 | 584.9 kb | Distal (>10kb) Multiome HiCAR | 52 |
Genomic view of the CSMD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.