The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for CSF3R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSF3R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSF3R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:36,187,827–36,188,464 | 293.8 kb | Distal (>10kb) Multiome | 572 | |
| chr1:36,223,459–36,225,047 | 257.7 kb | Distal (>10kb) Multiome | 1017 | |
| chr1:36,305,654–36,307,599 | 175.1 kb | Distal (>10kb) Multiome | 826 | |
| chr1:36,320,781–36,321,934 | 160.7 kb | Distal (>10kb) Multiome | 522 | |
| chr1:36,322,032–36,324,527 | 158.3 kb | Distal (>10kb) Multiome | 699 | |
| chr1:36,384,603–36,387,142 | 96.0 kb | Distal (>10kb) Multiome | 1050 | |
| chr1:36,387,290–36,388,127 | 94.3 kb | Distal (>10kb) Multiome | 280 | |
| chr1:36,397,267–36,398,140 | 84.1 kb | Distal (>10kb) Multiome | 787 | |
| chr1:36,400,687–36,401,905 | 80.7 kb | Distal (>10kb) Multiome | 721 | |
| chr1:36,449,991–36,450,940 | 31.5 kb | Distal (>10kb) Multiome | 725 | |
| chr1:36,463,701–36,464,970 | 17.6 kb | Distal (>10kb) Multiome | 1027 | |
| chr1:36,481,699–36,482,274 | 13 bp | At TSS Multiome | 133 | |
| chr1:36,736,272–36,736,888 | 254.5 kb | Distal (>10kb) Multiome | 32 | |
| chr1:36,764,371–36,765,397 | 282.9 kb | Distal (>10kb) Multiome | 194 | |
| chr1:36,770,003–36,772,181 | 288.4 kb | Distal (>10kb) Multiome | 297 |
Genomic view of the CSF3R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.