This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for CRIPT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRIPT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRIPT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:46,499,830–46,500,537 | 116.1 kb | Distal (>10kb) Multiome | 657 | |
| chr2:46,541,624–46,542,151 | 74.5 kb | Distal (>10kb) Multiome | 610 | |
| chr2:46,542,212–46,544,274 | 73.9 kb | Distal (>10kb) Multiome | 785 | |
| chr2:46,616,071–46,617,512 | 640 bp | At TSS Multiome | 955 | |
| chr2:46,698,279–46,700,093 | 82.6 kb | Distal (>10kb) Multiome | 974 | |
| chr2:46,704,551–46,705,027 | 88.4 kb | Distal (>10kb) Multiome | 109 | |
| chr2:46,915,163–46,916,556 | 299.5 kb | Distal (>10kb) Multiome | 931 |
Genomic view of the CRIPT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.