Predicted to enable chromatin binding activity. Predicted to be involved in pattern specification process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CRAMP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRAMP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRAMP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,331,603–1,332,817 | 280.3 kb | Distal (>10kb) Multiome | 492 | |
| chr16:1,333,312–1,334,056 | 278.7 kb | Distal (>10kb) Multiome | 271 | |
| chr16:1,342,604–1,343,805 | 269.1 kb | Distal (>10kb) Multiome | 560 | |
| chr16:1,351,418–1,352,242 | 260.4 kb | Distal (>10kb) Multiome | 733 | |
| chr16:1,378,844–1,380,439 | 232.6 kb | Distal (>10kb) Multiome | 782 | |
| chr16:1,408,010–1,408,819 | 204.0 kb | Distal (>10kb) Multiome | 546 | |
| chr16:1,413,643–1,415,278 | 197.6 kb | Distal (>10kb) Multiome | 661 | |
| chr16:1,420,269–1,421,402 | 191.5 kb | Distal (>10kb) Multiome | 897 | |
| chr16:1,474,566–1,475,411 | 137.2 kb | Distal (>10kb) Multiome | 915 | |
| chr16:1,492,797–1,493,962 | 119.0 kb | Distal (>10kb) Multiome | 710 | |
| chr16:1,610,035–1,611,264 | 1.7 kb | Proximal (<10kb) Multiome | 745 | |
| chr16:1,611,870–1,612,834 | 110 bp | At TSS Multiome | 718 | |
| chr16:1,614,100–1,614,386 | 1.8 kb | Proximal (<10kb) | 122 | |
| chr16:1,677,899–1,679,024 | 65.9 kb | Distal (>10kb) Multiome | 709 | |
| chr16:1,705,380–1,706,702 | 93.8 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,763,511–1,764,353 | 151.7 kb | Distal (>10kb) Multiome | 261 | |
| chr16:1,770,847–1,771,973 | 159.2 kb | Distal (>10kb) Multiome | 485 | |
| chr16:1,772,565–1,774,049 | 161.1 kb | Distal (>10kb) Multiome | 956 | |
| chr16:1,781,749–1,783,420 | 170.4 kb | Distal (>10kb) Multiome | 761 | |
| chr16:1,826,102–1,827,535 | 214.6 kb | Distal (>10kb) Multiome | 1006 |
Genomic view of the CRAMP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.