This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for CPE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:165,112,149–165,113,934 | 266.1 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr4:165,206,424–165,208,519 | 171.3 kb | Distal (>10kb) Multiome | 645 | |
| chr4:165,326,454–165,328,403 | 51.5 kb | Distal (>10kb) Multiome | 919 | |
| chr4:165,378,748–165,380,262 | 76 bp | At TSS Multiome | 796 | |
| chr4:165,380,954–165,381,094 | 1.9 kb | Proximal (<10kb) | 20 | |
| chr4:165,383,752–165,384,923 | 5.3 kb | Proximal (<10kb) Multiome | 263 | |
| chr4:165,493,149–165,493,950 | 114.5 kb | Distal (>10kb) Multiome | 270 |
Genomic view of the CPE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.