This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CORO2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CORO2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CORO2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,922,022–97,923,085 | 270.2 kb | Distal (>10kb) Multiome | 1110 | |
| chr9:97,982,380–97,985,451 | 207.9 kb | Distal (>10kb) Multiome | 994 | |
| chr9:98,056,283–98,057,271 | 136.0 kb | Distal (>10kb) Multiome | 868 | |
| chr9:98,087,291–98,088,183 | 104.9 kb | Distal (>10kb) Multiome | 281 | |
| chr9:98,118,693–98,119,508 | 73.5 kb | Distal (>10kb) Multiome | 752 | |
| chr9:98,191,695–98,193,531 | 366 bp | At TSS Multiome | 795 | |
| chr9:98,218,786–98,219,246 | 26.4 kb | Distal (>10kb) Multiome | 178 | |
| chr9:98,255,174–98,256,530 | 63.2 kb | Distal (>10kb) Multiome | 905 | |
| chr9:98,265,141–98,265,693 | 72.9 kb | Distal (>10kb) Multiome | 26 | |
| chr9:98,280,310–98,281,125 | 88.1 kb | Distal (>10kb) Multiome | 235 | |
| chr9:98,315,414–98,316,053 | 123.1 kb | Distal (>10kb) Multiome | 373 |
Genomic view of the CORO2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.