This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for CORO1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CORO1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CORO1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:108,441,995–108,442,516 | 289.3 kb | Distal (>10kb) Multiome | 196 | |
| chr12:108,514,776–108,515,777 | 216.4 kb | Distal (>10kb) Multiome | 685 | |
| chr12:108,560,717–108,561,713 | 170.3 kb | Distal (>10kb) Multiome | 703 | |
| chr12:108,561,872–108,563,300 | 169.0 kb | Distal (>10kb) Multiome | 772 | |
| chr12:108,691,447–108,691,929 | 39.8 kb | Distal (>10kb) Multiome | 745 | |
| chr12:108,730,199–108,732,667 | 342 bp | At TSS Multiome | 993 | |
| chr12:108,802,154–108,802,651 | 70.8 kb | Distal (>10kb) Multiome | 135 | |
| chr12:108,856,753–108,858,260 | 126.2 kb | Distal (>10kb) Multiome | 698 |
Genomic view of the CORO1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.