The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COPE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:18,635,894–18,637,555 | 282.7 kb | Distal (>10kb) Multiome | 617 | |
| chr19:18,682,925–18,684,360 | 235.7 kb | Distal (>10kb) Multiome | 701 | |
| chr19:18,785,146–18,785,600 | 134.0 kb | Distal (>10kb) Multiome | 247 | |
| chr19:18,831,386–18,833,070 | 87.5 kb | Distal (>10kb) Multiome | 833 | |
| chr19:18,870,063–18,870,526 | 48.9 kb | Distal (>10kb) Multiome | 148 | |
| chr19:18,895,036–18,896,591 | 23.2 kb | Distal (>10kb) Multiome HiCAR | 554 | |
| chr19:18,918,971–18,919,972 | 169 bp | At TSS Multiome | 828 | |
| chr19:18,932,038–18,933,012 | 13.1 kb | Distal (>10kb) Multiome | 312 | |
| chr19:18,940,835–18,941,417 | 21.9 kb | Distal (>10kb) Multiome | 336 | |
| chr19:19,017,061–19,017,561 | 97.9 kb | Distal (>10kb) Multiome | 21 | |
| chr19:19,032,820–19,034,059 | 114.3 kb | Distal (>10kb) Multiome | 944 | |
| chr19:19,063,253–19,064,386 | 144.4 kb | Distal (>10kb) Multiome | 781 | |
| chr19:19,105,310–19,106,514 | 186.3 kb | Distal (>10kb) Multiome | 447 | |
| chr19:19,110,429–19,110,857 | 191.3 kb | Distal (>10kb) Multiome | 131 | |
| chr19:19,119,998–19,121,362 | 201.2 kb | Distal (>10kb) Multiome | 304 | |
| chr19:19,138,171–19,138,698 | 219.1 kb | Distal (>10kb) Multiome | 642 | |
| chr19:19,170,055–19,170,692 | 251.0 kb | Distal (>10kb) Multiome | 403 | |
| chr19:19,191,912–19,193,209 | 273.2 kb | Distal (>10kb) Multiome | 939 | |
| chr19:19,202,895–19,203,773 | 284.1 kb | Distal (>10kb) Multiome | 599 |
Genomic view of the COPE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.