In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COPA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:160,046,290–160,047,082 | 296.6 kb | Distal (>10kb) Multiome | 540 | |
| chr1:160,069,829–160,071,049 | 272.8 kb | Distal (>10kb) Multiome | 419 | |
| chr1:160,083,809–160,084,575 | 259.0 kb | Distal (>10kb) Multiome | 327 | |
| chr1:160,095,707–160,096,231 | 247.3 kb | Distal (>10kb) Multiome | 79 | |
| chr1:160,097,214–160,099,572 | 244.4 kb | Distal (>10kb) Multiome | 659 | |
| chr1:160,100,845–160,101,543 | 242.1 kb | Distal (>10kb) Multiome | 530 | |
| chr1:160,169,049–160,170,141 | 173.6 kb | Distal (>10kb) Multiome | 330 | |
| chr1:160,192,913–160,193,769 | 150.0 kb | Distal (>10kb) Multiome | 551 | |
| chr1:160,204,860–160,206,035 | 137.8 kb | Distal (>10kb) Multiome | 637 | |
| chr1:160,261,515–160,263,143 | 80.8 kb | Distal (>10kb) Multiome | 992 | |
| chr1:160,284,609–160,285,332 | 58.1 kb | Distal (>10kb) Multiome | 638 | |
| chr1:160,342,945–160,343,700 | 53 bp | At TSS Multiome | 868 | |
| chr1:160,399,764–160,401,441 | 57.2 kb | Distal (>10kb) Multiome | 590 | |
| chr1:160,539,925–160,540,644 | 197.0 kb | Distal (>10kb) Multiome | 479 | |
| chr1:160,619,659–160,620,443 | 276.8 kb | Distal (>10kb) Multiome | 187 |
Genomic view of the COPA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.