Enables NF-kappaB binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COMMD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COMMD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COMMD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:32,456,960–32,457,933 | 286.0 kb | Distal (>10kb) Multiome | 407 | |
| chr20:32,482,216–32,484,943 | 259.8 kb | Distal (>10kb) Multiome | 976 | |
| chr20:32,521,770–32,522,231 | 221.5 kb | Distal (>10kb) Multiome | 550 | |
| chr20:32,535,878–32,537,141 | 206.9 kb | Distal (>10kb) Multiome | 665 | |
| chr20:32,582,894–32,585,976 | 160.2 kb | Distal (>10kb) Multiome | 755 | |
| chr20:32,742,092–32,742,834 | 1.1 kb | Proximal (<10kb) Multiome | 246 | |
| chr20:32,743,320–32,743,654 | at TSS | At TSS | 629 | |
| chr20:32,743,843–32,744,515 | 474 bp | At TSS Multiome | 356 | |
| chr20:32,749,988–32,750,256 | 6.5 kb | Proximal (<10kb) | 107 | |
| chr20:32,761,666–32,763,859 | 18.8 kb | Distal (>10kb) Multiome | 903 | |
| chr20:32,764,497–32,765,161 | 21.4 kb | Distal (>10kb) Multiome | 223 | |
| chr20:32,819,557–32,820,685 | 76.6 kb | Distal (>10kb) Multiome | 907 | |
| chr20:32,950,448–32,950,932 | 207.2 kb | Distal (>10kb) Multiome | 85 | |
| chr20:32,974,370–32,975,976 | 231.6 kb | Distal (>10kb) Multiome | 138 | |
| chr20:32,976,142–32,976,882 | 233.1 kb | Distal (>10kb) Multiome | 240 | |
| chr20:33,014,111–33,015,188 | 271.1 kb | Distal (>10kb) Multiome | 255 |
Genomic view of the COMMD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.