Enables several functions, including phosphatidylinositol-3,4-bisphosphate binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including Golgi to plasma membrane transport; negative regulation of protein localization to cell surface; and regulation of protein metabolic process. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity. Located in cytosol; endosome; and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COMMD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COMMD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COMMD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:61,694,419–61,695,205 | 210.9 kb | Distal (>10kb) Multiome | 599 | |
| chr2:61,763,751–61,764,826 | 141.3 kb | Distal (>10kb) Multiome | 975 | |
| chr2:61,787,728–61,788,473 | 117.5 kb | Distal (>10kb) Multiome | 51 | |
| chr2:61,793,349–61,793,828 | 112.1 kb | Distal (>10kb) Multiome | 309 | |
| chr2:61,853,553–61,855,487 | 51.7 kb | Distal (>10kb) Multiome | 973 | |
| chr2:61,888,195–61,889,300 | 17.0 kb | Distal (>10kb) Multiome | 1042 | |
| chr2:61,905,370–61,906,012 | 4 bp | At TSS Multiome | 819 | |
| chr2:61,924,970–61,925,711 | 19.8 kb | Distal (>10kb) Multiome | 28 | |
| chr2:62,108,942–62,110,921 | 204.3 kb | Distal (>10kb) Multiome | 186 | |
| chr2:62,194,988–62,196,964 | 290.4 kb | Distal (>10kb) Multiome | 910 | |
| chr2:62,370,563–62,371,206 | 465.3 kb | Distal (>10kb) Multiome HiCAR | 41 |
Genomic view of the COMMD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.