Enables cadherin binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for COBLL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COBLL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COBLL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:164,620,578–164,623,147 | 220.8 kb | Distal (>10kb) Multiome | 656 | |
| chr2:164,780,479–164,781,859 | 61.3 kb | Distal (>10kb) Multiome | 133 | |
| chr2:164,839,276–164,839,409 | 2.8 kb | Proximal (<10kb) | 25 | |
| chr2:164,840,552–164,842,740 | 767 bp | At TSS Multiome | 1021 | |
| chr2:165,067,939–165,068,602 | 226.1 kb | Distal (>10kb) Multiome | 259 | |
| chr2:165,069,502–165,070,514 | 228.0 kb | Distal (>10kb) Multiome | 159 |
Genomic view of the COBLL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.