This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CNTRL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNTRL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNTRL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:120,730,681–120,731,453 | 344.0 kb | Distal (>10kb) Multiome HiCAR | 456 | |
| chr9:120,792,955–120,793,917 | 281.5 kb | Distal (>10kb) Multiome | 991 | |
| chr9:120,842,458–120,843,456 | 231.9 kb | Distal (>10kb) Multiome | 838 | |
| chr9:120,868,216–120,869,551 | 206.1 kb | Distal (>10kb) Multiome | 643 | |
| chr9:120,873,261–120,874,043 | 201.3 kb | Distal (>10kb) Multiome | 247 | |
| chr9:120,875,854–120,877,760 | 198.7 kb | Distal (>10kb) Multiome | 982 | |
| chr9:120,928,372–120,929,413 | 146.0 kb | Distal (>10kb) Multiome | 626 | |
| chr9:121,074,349–121,075,511 | 49 bp | At TSS Multiome | 1041 | |
| chr9:121,121,551–121,122,082 | 46.8 kb | Distal (>10kb) Multiome | 539 | |
| chr9:121,201,011–121,202,492 | 127.0 kb | Distal (>10kb) Multiome | 850 | |
| chr9:121,221,026–121,221,471 | 146.4 kb | Distal (>10kb) Multiome | 78 | |
| chr9:121,267,686–121,269,264 | 193.1 kb | Distal (>10kb) Multiome | 550 | |
| chr9:121,286,406–121,287,700 | 212.4 kb | Distal (>10kb) Multiome | 735 | |
| chr9:121,299,542–121,300,058 | 224.8 kb | Distal (>10kb) Multiome | 428 | |
| chr9:121,369,661–121,370,788 | 295.4 kb | Distal (>10kb) Multiome | 849 |
Genomic view of the CNTRL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.