This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for CNTFR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNTFR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNTFR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,328,711–34,329,961 | 260.7 kb | Distal (>10kb) Multiome | 768 | |
| chr9:34,363,597–34,364,212 | 226.2 kb | Distal (>10kb) Multiome | 104 | |
| chr9:34,374,953–34,375,681 | 214.9 kb | Distal (>10kb) Multiome | 432 | |
| chr9:34,376,008–34,377,655 | 213.1 kb | Distal (>10kb) Multiome | 779 | |
| chr9:34,379,248–34,381,674 | 209.2 kb | Distal (>10kb) Multiome | 763 | |
| chr9:34,456,881–34,459,235 | 131.5 kb | Distal (>10kb) Multiome | 704 | |
| chr9:34,522,211–34,523,972 | 66.9 kb | Distal (>10kb) Multiome HiCAR | 473 | |
| chr9:34,577,374–34,578,752 | 12.1 kb | Distal (>10kb) Multiome | 204 | |
| chr9:34,585,537–34,586,582 | 3.1 kb | Proximal (<10kb) | 78 | |
| chr9:34,589,298–34,591,068 | 307 bp | At TSS Multiome | 258 | |
| chr9:34,591,283–34,592,013 | 1.7 kb | Proximal (<10kb) Multiome | 368 | |
| chr9:34,593,042–34,593,237 | 3.3 kb | Proximal (<10kb) | 118 | |
| chr9:34,611,663–34,612,738 | 22.0 kb | Distal (>10kb) Multiome | 680 | |
| chr9:34,612,834–34,613,263 | 23.0 kb | Distal (>10kb) Multiome | 343 | |
| chr9:34,620,108–34,620,704 | 30.4 kb | Distal (>10kb) Multiome | 467 | |
| chr9:34,628,770–34,629,308 | 38.9 kb | Distal (>10kb) Multiome | 216 | |
| chr9:34,637,123–34,638,475 | 47.7 kb | Distal (>10kb) Multiome | 872 | |
| chr9:34,646,247–34,647,338 | 56.6 kb | Distal (>10kb) Multiome | 857 | |
| chr9:34,651,771–34,652,431 | 62.0 kb | Distal (>10kb) Multiome | 669 | |
| chr9:34,664,346–34,666,446 | 75.4 kb | Distal (>10kb) Multiome | 707 | |
| chr9:34,674,895–34,675,574 | 85.1 kb | Distal (>10kb) Multiome | 372 | |
| chr9:34,701,127–34,701,863 | 111.3 kb | Distal (>10kb) Multiome | 390 |
Genomic view of the CNTFR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.