Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; and positive regulation of sodium ion transport. Predicted to act upstream of or within positive regulation of sodium ion transmembrane transporter activity. Predicted to be located in apical plasma membrane and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CNKSR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNKSR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNKSR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:154,155,927–154,157,111 | 354.3 kb | Distal (>10kb) Multiome HiCAR | 311 | |
| chr6:154,343,492–154,344,379 | 166.6 kb | Distal (>10kb) Multiome | 253 | |
| chr6:154,500,960–154,501,131 | 9.6 kb | Proximal (<10kb) | 137 | |
| chr6:154,509,167–154,511,379 | 5 bp | At TSS Multiome | 984 | |
| chr6:154,511,491–154,512,525 | 806 bp | At TSS | 270 | |
| chr6:154,512,788–154,513,047 | 2.1 kb | Proximal (<10kb) | 32 | |
| chr6:154,513,965–154,514,145 | 3.3 kb | Proximal (<10kb) | 181 | |
| chr6:154,542,675–154,543,191 | 32.3 kb | Distal (>10kb) Multiome | 171 | |
| chr6:154,645,535–154,646,800 | 135.7 kb | Distal (>10kb) Multiome | 96 | |
| chr6:154,652,848–154,653,591 | 142.6 kb | Distal (>10kb) Multiome | 127 | |
| chr6:154,732,598–154,734,903 | 223.5 kb | Distal (>10kb) Multiome | 1110 |
Genomic view of the CNKSR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.