Predicted to enable signaling receptor binding activity. Predicted to be involved in immune response and signal transduction. Predicted to be located in ER to Golgi transport vesicle membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CNIH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNIH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNIH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:54,187,126–54,188,017 | 253.8 kb | Distal (>10kb) Multiome | 54 | |
| chr14:54,291,237–54,292,121 | 149.8 kb | Distal (>10kb) Multiome | 321 | |
| chr14:54,361,880–54,362,724 | 79.1 kb | Distal (>10kb) Multiome | 146 | |
| chr14:54,366,777–54,367,506 | 74.4 kb | Distal (>10kb) Multiome | 393 | |
| chr14:54,396,464–54,397,605 | 44.5 kb | Distal (>10kb) Multiome | 808 | |
| chr14:54,440,764–54,441,825 | 124 bp | At TSS Multiome | 860 | |
| chr14:54,472,369–54,472,855 | 31.2 kb | Distal (>10kb) Multiome | 154 | |
| chr14:54,488,387–54,489,472 | 47.6 kb | Distal (>10kb) Multiome | 922 | |
| chr14:54,509,366–54,510,519 | 68.4 kb | Distal (>10kb) Multiome | 801 | |
| chr14:54,564,898–54,567,596 | 123.9 kb | Distal (>10kb) Multiome | 963 | |
| chr14:54,567,716–54,568,327 | 126.7 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the CNIH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.