This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for CMPK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMPK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMPK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:47,179,069–47,179,667 | 154.5 kb | Distal (>10kb) Multiome | 660 | |
| chr1:47,192,732–47,193,390 | 140.7 kb | Distal (>10kb) Multiome | 573 | |
| chr1:47,208,388–47,208,956 | 125.2 kb | Distal (>10kb) Multiome | 76 | |
| chr1:47,307,736–47,308,358 | 25.7 kb | Distal (>10kb) Multiome | 63 | |
| chr1:47,313,819–47,314,595 | 19.5 kb | Distal (>10kb) Multiome | 830 | |
| chr1:47,333,339–47,334,866 | 189 bp | At TSS Multiome | 912 | |
| chr1:47,416,109–47,417,449 | 83.0 kb | Distal (>10kb) Multiome | 138 | |
| chr1:47,424,446–47,424,949 | 90.9 kb | Distal (>10kb) Multiome | 274 | |
| chr1:47,432,258–47,433,058 | 98.9 kb | Distal (>10kb) Multiome | 298 | |
| chr1:47,436,505–47,439,686 | 104.1 kb | Distal (>10kb) Multiome | 844 | |
| chr1:47,449,968–47,450,449 | 116.3 kb | Distal (>10kb) Multiome | 195 | |
| chr1:47,523,548–47,524,329 | 190.3 kb | Distal (>10kb) Multiome | 53 | |
| chr1:47,532,955–47,534,409 | 199.7 kb | Distal (>10kb) Multiome | 323 | |
| chr1:47,593,089–47,593,546 | 259.5 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the CMPK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.