The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CLPP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLPP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLPP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:6,110,281–6,110,936 | 250.9 kb | Distal (>10kb) Multiome | 518 | |
| chr19:6,199,134–6,200,121 | 161.9 kb | Distal (>10kb) Multiome | 769 | |
| chr19:6,279,539–6,280,376 | 81.5 kb | Distal (>10kb) Multiome | 761 | |
| chr19:6,361,350–6,362,018 | 14 bp | At TSS Multiome | 803 | |
| chr19:6,372,272–6,374,427 | 11.9 kb | Distal (>10kb) Multiome | 925 | |
| chr19:6,392,902–6,394,077 | 31.9 kb | Distal (>10kb) Multiome | 767 | |
| chr19:6,423,613–6,425,899 | 63.6 kb | Distal (>10kb) Multiome | 956 | |
| chr19:6,458,960–6,460,940 | 98.8 kb | Distal (>10kb) Multiome | 859 | |
| chr19:6,463,863–6,464,838 | 102.7 kb | Distal (>10kb) Multiome | 526 | |
| chr19:6,470,903–6,471,589 | 109.7 kb | Distal (>10kb) Multiome | 26 | |
| chr19:6,475,386–6,477,353 | 115.0 kb | Distal (>10kb) Multiome | 419 | |
| chr19:6,515,952–6,517,331 | 154.6 kb | Distal (>10kb) Multiome | 732 | |
| chr19:6,530,842–6,531,584 | 169.4 kb | Distal (>10kb) Multiome | 640 | |
| chr19:6,551,766–6,552,224 | 190.5 kb | Distal (>10kb) Multiome | 403 | |
| chr19:6,656,104–6,656,671 | 294.9 kb | Distal (>10kb) Multiome | 10 | |
| chr19:6,661,103–6,661,799 | 300.0 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the CLPP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.