This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for CLMP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLMP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLMP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:122,976,845–122,977,850 | 217.9 kb | Distal (>10kb) Multiome | 198 | |
| chr11:122,981,561–122,982,103 | 213.3 kb | Distal (>10kb) Multiome | 237 | |
| chr11:122,984,138–122,985,025 | 210.7 kb | Distal (>10kb) Multiome | 184 | |
| chr11:123,061,397–123,063,188 | 132.8 kb | Distal (>10kb) Multiome | 997 | |
| chr11:123,108,059–123,109,666 | 86.0 kb | Distal (>10kb) Multiome | 58 | |
| chr11:123,166,097–123,166,614 | 29.0 kb | Distal (>10kb) Multiome | 131 | |
| chr11:123,168,860–123,170,139 | 25.3 kb | Distal (>10kb) Multiome | 127 | |
| chr11:123,194,428–123,196,820 | 1.0 kb | Proximal (<10kb) Multiome | 388 | |
| chr11:123,261,339–123,261,812 | 66.4 kb | Distal (>10kb) Multiome | 295 | |
| chr11:123,301,675–123,302,413 | 106.7 kb | Distal (>10kb) Multiome | 385 | |
| chr11:123,407,267–123,408,735 | 212.7 kb | Distal (>10kb) Multiome | 340 | |
| chr11:123,429,772–123,431,342 | 235.0 kb | Distal (>10kb) Multiome | 483 | |
| chr11:124,739,482–124,740,822 | 1544.7 kb | Distal (>10kb) Multiome HiCAR | 498 |
Genomic view of the CLMP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.