This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for CLINT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLINT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLINT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:157,574,988–157,576,496 | 283.2 kb | Distal (>10kb) Multiome | 533 | |
| chr5:157,651,151–157,652,376 | 207.4 kb | Distal (>10kb) Multiome | 337 | |
| chr5:157,670,928–157,672,025 | 187.7 kb | Distal (>10kb) Multiome | 295 | |
| chr5:157,731,147–157,732,116 | 127.5 kb | Distal (>10kb) Multiome | 887 | |
| chr5:157,743,286–157,744,563 | 115.5 kb | Distal (>10kb) Multiome | 750 | |
| chr5:157,855,459–157,855,714 | 3.4 kb | Proximal (<10kb) | 176 | |
| chr5:157,858,538–157,859,484 | 58 bp | At TSS Multiome | 749 | |
| chr5:157,913,392–157,915,108 | 54.6 kb | Distal (>10kb) Multiome HiCAR | 259 | |
| chr5:157,918,858–157,919,789 | 60.4 kb | Distal (>10kb) Multiome HiCAR | 265 | |
| chr5:157,948,652–157,949,339 | 89.9 kb | Distal (>10kb) Multiome HiCAR | 389 | |
| chr5:157,964,847–157,965,475 | 105.9 kb | Distal (>10kb) Multiome HiCAR | 76 | |
| chr5:158,094,160–158,095,038 | 235.5 kb | Distal (>10kb) Multiome | 184 | |
| chr5:158,135,426–158,136,207 | 276.7 kb | Distal (>10kb) Multiome | 169 | |
| chr5:159,099,838–159,101,146 | 1241.3 kb | Distal (>10kb) Multiome HiCAR | 500 |
Genomic view of the CLINT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.