CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for CLASP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLASP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLASP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:121,529,786–121,532,189 | 118.6 kb | Distal (>10kb) Multiome | 1343 | |
| chr2:121,648,584–121,650,422 | 162 bp | At TSS Multiome | 1043 | |
| chr2:121,680,120–121,680,609 | 30.9 kb | Distal (>10kb) Multiome | 87 | |
| chr2:121,736,354–121,737,978 | 87.6 kb | Distal (>10kb) Multiome | 878 | |
| chr2:121,745,785–121,746,842 | 96.9 kb | Distal (>10kb) Multiome | 195 | |
| chr2:121,754,998–121,756,033 | 106.1 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the CLASP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.