CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CKS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CKS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CKS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:89,179,706–89,180,739 | 130.8 kb | Distal (>10kb) Multiome | 598 | |
| chr9:89,225,983–89,226,479 | 84.9 kb | Distal (>10kb) Multiome | 72 | |
| chr9:89,295,298–89,295,875 | 15.6 kb | Distal (>10kb) Multiome | 98 | |
| chr9:89,309,551–89,310,009 | 1.2 kb | Proximal (<10kb) | 181 | |
| chr9:89,310,238–89,311,866 | 224 bp | At TSS Multiome | 945 | |
| chr9:89,317,972–89,319,093 | 7.5 kb | Proximal (<10kb) Multiome | 1083 | |
| chr9:89,435,291–89,435,862 | 124.3 kb | Distal (>10kb) Multiome | 216 | |
| chr9:89,497,231–89,498,509 | 186.9 kb | Distal (>10kb) Multiome | 374 | |
| chr9:89,603,012–89,604,575 | 292.0 kb | Distal (>10kb) Multiome | 537 | |
| chr9:89,604,751–89,607,232 | 295.6 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the CKS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.