This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CIT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CIT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CIT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:119,667,427–119,668,433 | 209.4 kb | Distal (>10kb) Multiome | 901 | |
| chr12:119,804,112–119,804,641 | 72.8 kb | Distal (>10kb) Multiome | 387 | |
| chr12:119,876,730–119,877,837 | 94 bp | At TSS Multiome | 609 | |
| chr12:119,988,471–119,990,364 | 112.8 kb | Distal (>10kb) Multiome | 892 | |
| chr12:120,086,807–120,087,619 | 209.9 kb | Distal (>10kb) Multiome | 957 | |
| chr12:120,093,667–120,094,287 | 216.7 kb | Distal (>10kb) Multiome | 172 | |
| chr12:120,116,125–120,117,765 | 239.6 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the CIT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.