The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CHST9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CHST9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CHST9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:26,956,953–26,957,443 | 228.2 kb | Distal (>10kb) Multiome | 152 | |
| chr18:27,143,002–27,143,205 | at TSS | At TSS | 45 | |
| chr18:27,143,709–27,143,884 | 671 bp | At TSS | 18 | |
| chr18:27,143,987–27,144,141 | 949 bp | At TSS | 57 | |
| chr18:27,150,141–27,150,536 | 7.1 kb | Proximal (<10kb) | 14 | |
| chr18:27,184,222–27,185,732 | 32 bp | At TSS Multiome | 298 | |
| chr18:27,223,493–27,224,314 | 38.6 kb | Distal (>10kb) Multiome | 94 | |
| chr18:27,232,221–27,232,687 | 47.2 kb | Distal (>10kb) Multiome | 91 |
Genomic view of the CHST9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.