This gene encodes a protein that plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Naturally occuring readthrough transcription occurs from this locus to the downstream t-complex 10 like (TCP10L) gene. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for CFAP298. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFAP298 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFAP298, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:32,305,933–32,306,620 | 306.3 kb | Distal (>10kb) Multiome | 126 | |
| chr21:32,392,560–32,393,703 | 219.6 kb | Distal (>10kb) Multiome HiCAR | 812 | |
| chr21:32,412,001–32,413,390 | 199.7 kb | Distal (>10kb) Multiome HiCAR | 469 | |
| chr21:32,432,983–32,433,635 | 179.3 kb | Distal (>10kb) Multiome | 99 | |
| chr21:32,569,288–32,570,076 | 42.9 kb | Distal (>10kb) Multiome | 731 | |
| chr21:32,601,081–32,601,264 | 2.0 kb | Proximal (<10kb) | 164 | |
| chr21:32,604,567–32,604,785 | 1.3 kb | Proximal (<10kb) | 78 | |
| chr21:32,612,057–32,613,158 | 13 bp | At TSS Multiome | 971 | |
| chr21:32,727,289–32,728,748 | 115.5 kb | Distal (>10kb) Multiome | 944 | |
| chr21:32,739,948–32,740,414 | 127.5 kb | Distal (>10kb) Multiome | 12 | |
| chr21:32,770,875–32,772,328 | 159.4 kb | Distal (>10kb) Multiome | 1027 |
Genomic view of the CFAP298 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.