Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CERS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CERS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CERS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,917,358–7,918,182 | 291.4 kb | Distal (>10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 288.7 kb | Distal (>10kb) Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 284.1 kb | Distal (>10kb) Multiome | 766 | |
| chr19:7,943,338–7,944,472 | 265.5 kb | Distal (>10kb) Multiome | 974 | |
| chr19:8,001,954–8,002,874 | 206.9 kb | Distal (>10kb) Multiome | 475 | |
| chr19:8,005,202–8,006,197 | 203.6 kb | Distal (>10kb) Multiome | 729 | |
| chr19:8,028,908–8,029,518 | 180.0 kb | Distal (>10kb) Multiome | 122 | |
| chr19:8,050,174–8,051,154 | 158.7 kb | Distal (>10kb) Multiome | 467 | |
| chr19:8,148,316–8,149,986 | 59.9 kb | Distal (>10kb) Multiome | 381 | |
| chr19:8,203,277–8,204,384 | 5.5 kb | Proximal (<10kb) Multiome | 150 | |
| chr19:8,208,086–8,210,178 | 173 bp | At TSS Multiome | 712 | |
| chr19:8,268,737–8,269,370 | 59.6 kb | Distal (>10kb) Multiome | 272 | |
| chr19:8,307,739–8,308,717 | 98.9 kb | Distal (>10kb) Multiome | 973 | |
| chr19:8,314,738–8,315,490 | 105.7 kb | Distal (>10kb) Multiome | 49 | |
| chr19:8,320,824–8,321,811 | 112.1 kb | Distal (>10kb) Multiome | 871 | |
| chr19:8,334,500–8,335,843 | 126.0 kb | Distal (>10kb) Multiome | 384 | |
| chr19:8,342,762–8,343,678 | 134.0 kb | Distal (>10kb) Multiome | 440 | |
| chr19:8,363,586–8,364,765 | 154.7 kb | Distal (>10kb) Multiome | 549 | |
| chr19:8,389,684–8,391,548 | 180.9 kb | Distal (>10kb) Multiome | 878 | |
| chr19:8,412,769–8,413,775 | 203.8 kb | Distal (>10kb) Multiome | 566 | |
| chr19:8,444,605–8,445,806 | 235.5 kb | Distal (>10kb) Multiome | 910 | |
| chr19:8,505,742–8,506,861 | 296.9 kb | Distal (>10kb) Multiome | 739 | |
| chr19:8,511,414–8,512,588 | 302.7 kb | Distal (>10kb) Multiome | 263 | |
| chr19:8,513,025–8,514,530 | 304.6 kb | Distal (>10kb) Multiome | 825 |
Genomic view of the CERS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.